425 Ras/Raf/MEK/ERK can be activated through distinct mechanisms: (1) a ligand-dependent route, where ligands, including hormones, growth factors, or cytokines, specifically bind to receptors and (2) a ligand-independent route, triggered by physical stressors like injury, radiation, or osmotic pressure
Advances in experimental medicine and biology, vol 1411
507 Although these studies have shown the safety of Mito-Q in long-term use, the safety assessment of a longer scale has not been fully studied
10.5937/leksir1636037k [DOI] [Google Scholar] Ko Y
L.ZhangX.Oyler-CastrilloP.et al
For the mass spectrometry, the data-dependent MS 2 scan conditions were applied in both positive and negative mode: the scan range was from m/z 2501500, resolution was 60,000 for MS, and 30,000 for DDMS 2 (top 10), and the AGC target was 3E 6 for full MS and 1E 5 for DDMS 2 , allowing ions to accumulate for up to 200 ms for MS and 50 ms for MS/MS