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30 The SPLENDID trial, a matched cohort study, compared 5053 patients with obesity with 25 265 nonsurgical matched controls, with a median age of 46 years and median follow-up of 6.1 years, showed an OAC risk reduction of 32%, (HR, 0.68
Margari et al., 2018)
Therefore, cancer cells enhance the cytosolic lactate fermentation to generate NADH by LDHA
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Small-molecule GLP1RAs promise oral bioavailability and scalable manufacturing, but their selective binding to human versus rodent receptors has limited mechanistic studies 4,5,6,7,8,9
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