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10.1128/IAI.00491-13 Infect

In contrast, direct central mechanisms including PI3K/Akt-mediated neuroprotection, BDNF upregulation, and enhanced autophagy are primarily supported by preclinical data obtained at drug concentrations substantially higher than those achievable in the human brain at therapeutic doses

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"Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro"