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The statistical testing strategy for the confirmatory secondary end points used a separate alpha spending function to control type I error rate at a 1-sided level of 2.5%, which aligned with the P value adjustment for the group sequential design

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PMID: 41122967 J Ethnopharmacol2023 Nov 15:316:116704

For convenience and needle aversion : Oral GHK-Cu is the easiest option, but understand that systemic benefits will be significantly limited by poor bioavailability