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NCT03819153) was a multicenter, double-blind, randomized (stratified according to the use of sodium-glucose cotransporter 2 [SGLT2] inhibitors at baseline), placebo-controlled clinical trial led by an academic steering committee and conducted at 387 international sites, with a median follow-up of 3.4 (interquartile range 2.94.0) years

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It interacts with the pro-apoptotic protein Bax, inhibiting its translocation to the mitochondria and preventing the release of cytochrome c (Hashimoto et al., 2001)

doi:10.1056/NEJMoa2028395

Those include Eliquis, Pfizer's blood thinner marketed with Bristol Myers Squibb, and Ibrance, a drug for advanced and metastatic breast cancer