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Poly (N-(2-hydroxypropyl) methacrylamide polymer) (pHPMA)-coated penetratin-insulin complex that has almost neutral surface charge showed enhanced mucus diffusion and insulin delivery in a diabetic rat model compared to nanoparticles whose surface charge is negative (Shan et al., 2015)

In this chapter, we explore how drug nanocrystals can be designed to improve ocular drug delivery , addressing key challenges such as poor drug solubility, limited ocular bioavailability, and the barriers associated with topical administration

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This causes the water in the vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure