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Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron

Details for tissue extraction, trypsin digestion, sample cleanup, and fractionation and liquid chromatographymass spectroscopy (LC-MS) analysis are described in Supplemental Methods

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Kynurenine (Kyn), primarily produced by fibroblasts, activates AhR, induces PTEN expression, and suppresses AKT/mTOR signaling, thereby reducing fibroblast migration and activation [117]

doi: 10.1016/j.bcdf.2019.100182 147

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