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Study variability Many of the studies assessed were of relatively low quality (case studies or small study groups) and were therefore underpowered, and potentially had selection biases due to unmeasured confounders

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Laboratory tests are usually normal, while those who suffer from the condition can be incapacitated and bed-bound in severe cases

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In some cases, hormonal imbalances may persist even after steroid cessation (Kanayama et al., 2008 Harvard Medical School )

By applying a reverse translational approach that evaluates compounds with emerging clinical efficacy, we demonstrated that semaglutide, tirzepatide, and retatrutide blunt alcohol interoceptive/subjective effects, potentially clarifying a clinically meaningful mechanism