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In case of neurologic symptoms or abnormalities, it is suggested to administer hydroxocobalamin, 1000 mg once or twice weekly for a period of up to 2 years, and the package insert for hydroxocobalamin has included these particular instructions for several decades

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The most studied dose in rodent models is 10 mcg/kg, with a studied range of about 1 to 50 mcg/kg

References: Mecobalamin: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia [Internet]