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It is best known for its role in supporting mitochondrial health since it is responsible for transporting fatty acid chains to the mitochondria within cells, where they are oxidised to produce energy

Phentermine is an FDA-approved medication for weight management, while topiramate is used off-label for weight loss

These are consistently undertrained and become more important as patients lose fat and want improved definition in the lower body

10.1016/j.actatropica.2021.105961 247 ZhouJ.ZhangN.AldhahraniA.SolimanM

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Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (which encodes the receptor every GLP-1 compound targets), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (a transcription factor tied to glucose handling and GLP-1 secretion) describe the terrain a compound has to work across