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Notably, genes encoding the master regulator of cholesterol, LXR (Nr1h2, Nr1h3), were decreased following semaglutide, whereas the gene encoding FXR (Nr1h4), which increases fatty acid oxidation in liver, was increased

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coli ( zntA was differentially expressed both in our findings and in the literature ( zntA as differentially expressed with a quarter of the exposure time may mean it is one of the first genes to change its expression in the face of zinc stress and these genes related to zinc homeostasis and efflux pumps might be fundamental to Zns role in AMR development in general

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