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The SURMOUNT-1 trial compared tirzepatide at 5mg, 10mg, and 15mg doses against placebo in adults with obesity

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The injection is administered intramuscularly, typically in the deltoid (upper arm) or gluteal (hip) region by a trained medical professional.

B12 shots provide a direct and fast way to restore B12 levels making them ideal for those with more significant deficiencies or health conditions that prevent proper absorption

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Single KOs were maintained through heterozygous breeding, while double KOs were bred homozygously and WT mice were age-matched controls