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Inflammatory mediators Tissue injury, however minor, initiates a localised inflammatory cascade involving histamine, prostaglandins, and cytokines, which sensitise nerve endings and cause the characteristic burning or stinging sensation

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The patients were on semaglutide for around a year before weaning off semaglutide over the course of 9 weeks

Fat tissue, particularly visceral fat around internal organs, releases inflammatory proteins that may worsen the neuroinflammation already present in MS