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Among three types of Aluminium Oxide (Al 2 O 3 ) NPs including pristine Al 2 O 3 NPs (p- Al 2 O 3 ), hydrophilic (w- Al 2 O 3 ), and lipophilic (o- Al 2 O 3 ), it was found that o-Al 2 O 3 NPs were more toxic than p-Al 2 O 3 and w-Al 2 O 3 NPs both in vitro and in vivo , as a result of cell membrane damage and over-production of ROS

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