Insulin resistance, hyperandrogenemia, and oxidative stress imbalance are the three critical pathological mechanisms involved in the development of PCOS, forming a vicious cycle [37, 38] that perpetuates the diseases progression
They require comprehensive services and treatment that span a continuum of care from emergency to short-term to longer term assistance
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For example, Liu et al
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To overcome the above-mentioned hurdles of intranasal drug delivery, peptides and proteins can be modified to increase their membrane permeability and stability, by supplementing the drug with enzyme inhibitors that perturb the pseudo-first-pass effects (Pires et al., 2009)