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In vivo , obesity and insulin resistance in mice were associated with GPx-1 overexpression, further supporting a dual role for GPx-1 in regulating different types of oxidative stress with a possible deleterious impact on metabolism, molecular, and physiological functions

However, the lack of targeted therapies in clinical practice contributes to a poor prognosis for patients with IIRI, which has a high mortality rate of 5069% [6]

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Both L-ARG and NAC donate thiol groups and reactivate oxidate gluthatione, also improving nitic oxide synthesis (36) (Fig

Neither is inherently superiorthey represent different therapeutic approaches