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Hanzlikova et al, 2017

Implications of Low Glutathione Levels Low levels of glutathione have been associated with increased susceptibility to kidney damage

Bleeding gums, anemia, and loss of appetite are also observed (246)

[28] Summary of the role of glutathione as a skin-lightening agent While there is no published data for intravenous glutathione, the results of the three randomized controlled trials mentioned above have provided grade Ib and 2b evidence in favour of the skin-lightening effects of topical and oral glutathione, with no significant adverse effects [Table - 1]

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It was found that the average skin weight of mice in the KO group was significantly decreased in a dose-dependent manner