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Further, despite the persistent notion that all diuretics might have diabetogenic properties, long-term studies in preclinical animal models are still missing and many questions remain unanswered regarding the mechanisms whereby these drugs may exert their metabolic effects under different chronic contexts

Primary Handling Editor: Sara Osman, in collaboration with the Nature Structural & Molecular Biology team

This unique mechanism of action sets retatrutide apart from traditional weight loss drugs such as semaglutide (Wegovy) as it aims to target all three of these key hormones involved in glucose (blood sugar levels) and satiety regulation

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And how do we make this choice when we dont know

A runny nose or mild headache may be uncomfortable, but it is different from severe abdominal pain, swelling, trouble breathing, or a blistering rash