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In these cases, animal and/or in vitro studies are considered

doi: 10.1186/s40348-019-0091-z 102

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Methods This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify and evaluate in vitro studies investigating the effects of glucagon-like peptide-1 receptor agonists and their analogues on human mesenchymal stem cell functions, including proliferation, differentiation, signaling, apoptosis, and tissue-specific applications

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Notably, erianin significantly inhibited tumor growth in a xenograft mouse model without notable toxicity (72)