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Buchmann AF, et al

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Research has indicated that HPA axis hyperactivity is heightened in chronic hyperglycemic states, with severe hyperglycemic events more likely to result in depressive disorders [71]

Overall, the fine-tuned regulation of vascular function is essential for cardiovascular homeostasis, and biologic-based therapies targeting NO signaling, Ca modulation, and metabolic vascular regulation represent promising avenues for improving vascular health and reducing cardiovascular risk (Fig

Peripheral arterial disease (PAD) Peripheral arterial disease is frequently underdiagnosed in type 2 diabetes, yet carries significant risks for cardiovascular events and limb complications [122]

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