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To exclude potential kinetic differences in the ability of DA to recruit -arrestin2 versus G i1 , time-course experiments showed that receptor stimulation by DA does not result in the recruitment of -arrestin2 at any of the time points tested (data not shown)

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We also observed frequent overlap between FOXO4 and p53bp1 foci, indicating an interaction and co-localization between FOXO4 and p53 in the nuclei of senescent cells (Figure