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However, the underlying mechanism by which MTX provokes tissue injury is not yet well known, and direct toxic effects of MTX are thought to be caused by excessive generation of free radicals, causing an imbalance between free radical production and antioxidant defense, which finally results in the development of oxidative stress (Drishya et al

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There can be tolerance with repeated use, which degrades efficacy and increases doses, leading to safety concerns

Low energy often improves after the first few weeks of treatment as your body adjusts

PubMed PMID 40756949, 2025

After submission, the licensed provider can adjust or recommend a different medication or protocol if clinically appropriate based on your intake, goals, medical history, and safety considerations