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The most common adverse effects of retatrutide were gastrointestinal (GI) such as nausea, diarrhea, vomiting and constipation reported by 13-50% in the retatrutide groups compared with 35% in the dulaglutide group, and 13% in the placebo group

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Final thoughts: Managing semaglutide and constipation Constipation is a common but manageable side effect of semaglutide medications like Ozempic and Wegovy

Employers should view these medications as one component of a broader obesity and metabolic health strategy, pairing medication use with lifestyle support, benefit coordination, and clear expectations around duration and outcomes

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