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Patients should have a consultation with their medical provider before initiating treatment so that proper treatment can be developed to reduce their associated risks while allowing for continual assessment of their treatment to help them achieve their goals.

Losing weight reduces the inflammatory burden but the timeline is nonlinear, and the pathways that drive inflammation (particularly NF-B signalling) do not simply switch off as body fat declines

The mechanism likely relates to changes in appetite regulation and energy metabolism

It does not bleach the skin

This makes it necessary to develop sustained or controlled release transdermal patches under second aspect