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Research has demonstrated that autoantibodies from APS patients, unlike those from asymptomatic antiphospholipid carriers, can induce eryptosis in RBCs from healthy donors in vitro

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They screened six differentially expressed ferroptosis-related genes (IL6, ANGPTL7, CDKN1A, AKR1C3, NOX4, and VLDLR) and constructed a random forest model based on these genes, which demonstrated strong diagnostic performance in the validation dataset, highlighting the close relationship between ferroptosis and immunity in atherosclerosis pathogenesis ( y axis involving XIST and OIP5-AS1/miR-216a/PIK3CA, which may play a critical role in regulating ferroptosis during AMI progression