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Headaches persisting beyond 48 weeks of stable dosing warrant medical review

References and Official Sources All coding rules, DRG groupings, and guideline citations in this article are sourced from official CMS, NCHS, and AAPC publications current as of FY 2026

This is typically observed at doses between 200 to 400 mg/day in healthy young adults, with some degree of individual variation (23, 24)

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