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Spinal injections, such as epidurals, are typically safe

Activity of 5-oxoprolinase in leukocytes and/or cultured fibroblasts can be measured according to the method described by Larsson et al

J Biol Chem 277:1132111328 Alonso JR, Cardellach F, Lopez S, Casademont J, Miro O (2003) Carbon monoxide specifically inhibits cytochrome C oxidase of human mitochondrial respiratory chain

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M., Coyle, R

The most commonly cited starting protocol in the medical literature and clinical practice involves 250 micrograms administered once daily for acute injury, stepping up to 500 micrograms daily if response is insufficient after one to two weeks