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Transforming growth factor-beta1 stimulates matrix metalloproteinase-9 production through ERK activation pathway and upregulation of Ets-1 protein

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Moreover, PIP2 is a substrate for phosphoinositide 3-kinase (PI3K), forming phosphatidylinositol (3,4,5)-trisphosphate (PIP3), a critical docking site for proteins in the insulin signaling pathway, including Akt (Protein Kinase B)

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