The Harmony Outcomes trial further revealed that albiglutide reduced MACE by 22% over a median follow-up period of 1.6 years in patients with type 2 diabetes and cardiovascular disease ( p = 0.0006) [70]
This serves to further consolidate Eli Lillys protection around the active ingredient tirzepatide and, therefore, its products Mounjaro and Zepbound
The good news is that these dysesthesia events were generally mild
Researchers theorize this may be because: GIP activation may counterbalance some GLP-1 effects on the gut Dose escalation schedule allows more gradual adaptation Different pharmacokinetic profile may produce less pronounced peaks Serious Side Effects (Both Medications): These are rare but require immediate medical attention: Pancreatitis: Severe abdominal pain that may radiate to the back Risk: Less than 1% with both medications Usually occurs in first few months of treatment Requires immediate discontinuation if suspected Gallbladder Problems: Gallstones, cholecystitis (gallbladder inflammation) Symptoms: Right upper abdominal pain, nausea, fever More common with rapid weight loss May require surgical intervention Kidney Problems: Dehydration from vomiting/diarrhea can affect kidney function Watch for decreased urination, swelling in legs Stay well-hydrated, especially during side effect periods Thyroid Tumors (Black Box Warning): Both medications carry warnings about thyroid C-cell tumors Based on rodent studies
Ozempic may also cause more serious side effects, such as pancreatitis and allergic reactions, though these are rare
Psyllium husk is a common dietary supplement that can help you increase your fiber intake and manage mild side effects from GLP-1 weight loss medication, such as constipation and diarrhea
