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GLP-1 RAs, such as exenatide and lixisenatide, have shown benefits in addressing the pathology of PD in animal studies and phase II clinical trials, halting progression and delaying worsening of symptoms

It is important to rotate the injection sites to avoid skin irritation and other issues

A fishy odor to the breath, sweat and urine has been reported

An emerging strategy among employers is to carve GLP-1s out of the core medical plan and offer access through a defined, employer-funded health reimbursement arrangement (HRA)

222 A systematic review and meta-analysis of 10 randomised-controlled trials of EPA/DHA in migraine found a significant reduction of approximately 3.44 hours in the duration of migraine, but no effect on frequency or severity

This makes it the preferred route when a patient cannot absorb B12 through the gastrointestinal tract