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Albuminuria-lowering effect of adding semaglutide on top of empagliflozin in individuals with type 2 diabetes: a randomized and placebo-controlled study

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Similarly, a small-scale sgRNA competition assay in HEK-293T SLC25A39 knockout and control cells infected with a pool of control and SLC25A40 sgRNAs confirmed these results under BSO treatment (Extended Data Fig

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To address this, we employed a sequential, multi-omics bioinformatics workflow to generate a testable mechanistic hypothesis, followed by rigorous experimental validation