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doi: 10.1016/j.tifs.2020.05.019 72

Levels are highest in the gut, where they directly fuel and regulate colon cells, and much lower in the bloodstream, where they still influence metabolism and immunity

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OPTN/SRTR 2023 annual data report: kidney

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Figure 5 3.4 Safety and tolerability of the B12 supplements All the B12 supplements were generally well tolerated by all participants in the three studies