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No clinically validated or universally accepted KLOW ratio was identified

Patients who are also suffering from gastrointestinal disorders, such as small intestinal bacterial overgrowth (SIBO), Celiac or Crohns may not be absorbing Vitamin B12 optimally due to an underlying inflammatory load and unfavourable microbiome

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Basic, practical questions remain, too such as what dose people should use, how long the compound lasts in different tissues and whether the product in a purchased vial actually matches its label