10.1038/srep29921 Sci
semaglutide should be discontinued at least two months before a planned pregnancy During treatment , patients should: Attend all scheduled follow-up appointments to monitor both metabolic parameters and general wellbeing Keep a symptom diary noting any mood changes, particularly in the first three months of treatment Maintain open communication with healthcare providers about any concerns, however minor they may seem Continue existing mental health treatments unless specifically advised otherwise by a psychiatrist Adopt healthy lifestyle measures including regular physical activity, adequate sleep, and balanced nutrition, which support both metabolic and mental health Be aware that hypoglycaemia risk increases when GLP-1 agonists are used with insulin or sulfonylureas, and dose adjustments of these medications may be needed Common adverse effects of GLP-1 agonists include nausea, vomiting, diarrhoea, and constipation, which typically improve over time
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The table below summarizes key safety markers from pivotal clinical data to support provider conversations
Moreover, among patients with bipolar disorder, cannabis users exhibited less compliance and higher level of overall illness severity compared with non-users (van Rossum et al., 2009)
However, they are not the whole answer
