Most of these visits (69.3%) were due to severe gastrointestinal adverse reactions
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Importantly, the cytokine transduces a pro-inflammatory signal from the periphery to the CNS through endothelial cells of the bloodbrain barrier [75, 76]
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But because the study involved a small number of people and the findings are from a retrospective chart review rather than a randomized study, they should be viewed as preliminary. Other doctors have concerns, too
[1] Insulin signaling also extends beyond traditional metabolic tissues