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Therapeutics 33 (3), 358371.e2

Melasma may be triggered by sun exposure, hormonal changes, cosmetic products that are irritating to the skin, stress, and thyroid disease

Cellular Migration and Communication Cells constantly exchange information through signaling molecules and receptor-mediated pathways

If B12 levels are low but still in range indicating a functional deficiency (this is a deficiency but blood tests appear in normal range) then second line testing of homocysteine and MMA can confirm B12 and/or folate deficiency

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sterile water is not presented as a preserved multi-access reagent