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Glucagon receptor agonism increases basal energy expenditure through stimulation of hepatic thermogenesis and fatty-acid turnover, and activates mitochondrial beta-oxidation

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The brain GIP receptor signalling pathways play a key role in the regulation of energy balance [25]

Interestingly, despite the lack of consistent actions of metformin in terms of metabolic profiles, treatment with the insulin sensitizer caused a complete normalization of ovarian cyclicity, pointing to a discernible reproductive effect of metformin in some PCOS conditions, in line with clinical literature 68 , although conflictive results have been reported also 69

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