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Low SAM, excessive methylation demand, impaired creatine synthesis, reduced glutathione availability and oxidative stress may place additional strain on mitochondria, potentially contributing to fatigue, variable cognitive stamina, sensory sensitivity, poor stress tolerance and slow recovery from illness

Bernardini S, Bernassola F, Cortese C, Ballerini S, Melino G, Motti C et al

Mitochondrial glutathione transport: Physiological, pathological and toxicological implications

For negative-mode acquisition, mobile phase A was 100% LCMS-grade H 2 O with 10 mM ammonium acetate, 0.1% ammonium hydroxide and 0.1% medronic acid (Agilent)

2011;7:539 Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJ