The copper binding occurs through a specific square-planar pyramid configuration involving nitrogen atoms from histidine and glycine, plus a deprotonated amide nitrogen and carboxyl oxygen from lysine
Mechanistic investigations revealed that nanoSe inhibits Huntington protein aggregation, reducing neuronal oxidative stressrelated mRNA levels, and downregulating the expression of histone deacetylase family members (HDAC1, HDAC4, and silent information regulator sirtuin 1)
Silicic acid or silicon dioxide in dietary supplements has been discouraged
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Therefore, a novel approach with a sufficient sensitivity range and robustness is extremely desirable