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According to a randomized controlled trial, tapentadol (100250 mg) was effective and well tolerated for the management of moderate-to-severe chronic pain associated with DPN [131]

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Individuals with gut motility issues like gastroparesis

Topiramate is typically taken orally once or twice daily, with doses for migraine prevention usually between 50100 mg daily (maximum 200 mg daily), while epilepsy treatment may require higher doses