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Future investigation should also clarify whether the benefit is driven by direct antitumor effects of GLP-1 RAs or by indirect mechanisms mediated through weight loss and cardiometabolic risk reduction

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Both BNP [132] and BNP [332] stimulate production of cGMP

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Unlike native -MSH, which has a very short plasma half-life due to rapid enzymatic degradation, MT-1 incorporates a linear sequence modification that significantly extends its stability in biological matrices while preserving high-affinity binding at melanocortin receptors primarily MC1R, the receptor responsible for eumelanin synthesis in melanocytes