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These findings suggest that NAC should be used at a dose 1200 mg/day to prevent exacerbations in patients with a chronic bronchitis phenotype of COPD and airway obstruction, while regular doses (600 mg/day) may be sufficient in the absence of airway obstruction [37]

10.3389/fendo.2018.00061 151 ReganS

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However, significant translational barriers remain: no human pharmacokinetic data, high synthesis cost, unknown long-term safety, and the absence of clinical trials

i , Relative RPKM values of SLC25A39, FTL and HBB genes in human erythroblasts at differing stages of terminal differentiation