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Brain 127, 10611074

Phase 2 clinical trials enrolled 338 participants and tracked outcomes over 48 weeks

AAIC 2026 This article summarizes research and is not medical advice

This is not an oral version of Lillys highly successful Zepbound, rather, it is a single mechanism GLP1 drug, not a dual mechanism

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate