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Different genetic variants are associated with increased or decreased responses to GLP-1 RA drugs for diabetes or weight loss

The safety section says semaglutide at any dose requires baseline kidney function assessment and periodic monitoring, particularly as doses rise

In most cases, semaglutide continues to work

Moreover, septic complications can occur so patients should be closely observed for fever and urinary problems

69 articles were fully reviewed on second screening

In terms of tolerability, GI side effects remain the leading cause of treatment discontinuation, yet optimal prevention and management strategies require further refinement