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Experimental data shows that the affinity of IGF-1 LR3 for IGF-1R is twice that of natural IGF-1, and its affinity for insulin receptor (IR) is reduced by 100 times, reducing the risk of hypoglycemia

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although their phagocytic activity and release of neutrophil extracellular traps (NETs) contribute to pathogen clearance, excessive activation and dysregulated NET formation cause direct tissue injury (Long et al., 2024)

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Phylogenetic analysis of the preproglucagon amino acid sequence in vertebrates revealed expected tree topology but also highlights sequence divergence in the monotreme lineage (Fig