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(5) Exclusion of Cell and Gene Therapies From the C-APC Policy As previously discussed in this section, and in the CY 2014 OPPS/ASC final rule with comment period (78 FR 74865), the C-APC policy packages payment for items and services that are typically integral, ancillary, supportive, dependent, or adjunctive to the primary service and provided during the delivery of the comprehensive service, including diagnostic procedures, laboratory tests and other diagnostic tests and treatments that assist in the delivery of the primary procedure

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Research protocols investigating long-term melanocortin signaling typically employ intermittent dosing schedules for this reason