In the present study, a mouse model of chronic oxidative stress due to compromised de novo GSH synthesis (GCLM KO) 16 exhibited unexpected protection from chronic alcohol consumption-induced hepatotoxicity and steatosis
Reduced glutathione had significant affinity for ascorbic acid, opioids and adrenergic compounds as well as serotoninergic compounds, but not for other neurotransmitters or glucose
Multiple functions of peroxiredoxins: Peroxidases, sensors and regulators of the intracellular messenger H2O2, and protein chaperones
In the regulation of innate immunity, the lack of the expression of NRF-2 entails a disturbance in the protective process of the host, as well as increased damage by hyperoxia, the increase of ROS, and inefficiency in the elimination and increase in the production of proinflammatory cytokines [28,29]
Negishi, Y., Nobusada, K
Zabel M, Nackenoff A, Kirsch WM, Harrison FE, Perry G, Schrag M