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Extracted samples were vortexed at 4 C for 10 min, cleared by centrifugation (17,000 g , 10 min, 4 C) and then supernatants were analysed by LCMS

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and (ii) proliferative astrogliosis, which is anisomorphic with loss of domain, substantial structural reorganisation and can either be diffuse or can result in the formation of new compact limitans borders around overt fibrotic tissue lesions (Fig

Certain urinary tract infections increase the risk of struvite stones