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Patches maybe worn for up to 12 hours before discarding

The increase in creatinine is primarily due to elevated creatine stores in the muscles, which leads to higher breakdown rates

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10.1248/cpb.35.1910 130 ShinD.LeeS.HuangY.-H.LimH.-W.LeeY.JangK.et al (2018)

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Stating the question differently: Is hypohomocysteinemia associated with metabolic dysfunction or disease