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The results according to the authors were that Acute ingestion of p-synephrine increased the rate of fat oxidation while reducing the rate of carbohydrate oxidation when exercising at low to moderate exercise intensities. Figure 15: Fat oxidation rate (upper panel) and carbohydrates (lower panel) during exercise of increasing intensity 1 h after ingestion of 3 mg/Kg of p-synephrine or a placebo

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PMID 3528148

Segmented filamentous bacteria ( SFB ) in the mouse gut promote the production of IL-17 and IFN- and play key roles in both osteoclast and osteoblast formation (221223), indicating that the GM modulates bone metabolism by altering the host immune status

In vitro research show that quercetin inhibits CYP2D6